Hepatoid adenocarcinoma of the stomach : report of five cases and review of the literature
| Journal | Volume 69 - 2006 |
| Issue | Fasc.3 - Case reports |
| Author(s) | Tulay Bakir, Yuksel Aliyazıcıoglu, Ahmet Bektas, Cigdem Siviloglu, Orhan Ozgur |
| Full article |
 VIEW FREE PDF |
| Departments of (1) Gastroenterology, (2) Biochemistry, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey ; (3) Pathology Unit, Numune Hospital, Trabzon, Turkey ; (4) Department of Gastroenterology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. |
|
We report on a rare hepatoid adenocarcinoma of the stomach producing alpha-fetoprotein (AFP) in five cases. Definitive fea- tures included an aggressive, invasive, and rapidly progressing neoplasm showing areas morphologically comparable to those of hepatocellular carcinomas. All patients had multiple metastases to lymph nodes and/or liver. The serum AFP level of the patients was between 83-87.900 ng/ml. Two subtotal and one palliative gastrec- tomy was performed. A short duration of chemotherapy was administered only in two patients. The length of survival averaged 4.7 months. Our experience together with what has been reported in literature suggest that the course of hepatoid adenocarcinoma of the stomach is more aggressive than an ordinary adenocarcino- ma and that from a diagnostic point of view distinction from an adenocarcinoma may be accomplished histochemically and by measuring serum AFP levels. (Acta gastroenterol. belg., 2006, 69, 330-337). |
|
© Acta Gastro-Enterologica Belgica. |
